Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson’s Disease
Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson’s Disease
Auteurs : Anam Qudrat [Canada] ; Netra Unni [Canada]Source :
- The Yale Journal of Biology and Medicine [ 0044-0086 ] ; 2016.
Abstract
Parkinson’s disease is a late-onset neurodegenerative disease, characterized by both motor and non-motor symptoms. Motor symptoms include postural instability, rigidity, and tremor, while non-motor symptoms include anxiety, dementia, and depression. In this integrative review, we discuss PD disease pathophysiology in detail and introduce how neurotrophic growth factor delivery via a retroviral-based system can be used as efficacious tools for targeted gene therapy.
Url:
PubMed: 27354847
PubMed Central: 4918865
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson’s Disease</title><author><name sortKey="Qudrat, Anam" sort="Qudrat, Anam" uniqKey="Qudrat A" first="Anam" last="Qudrat">Anam Qudrat</name><affiliation wicri:level="4"><nlm:aff id="A1">Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Unni, Netra" sort="Unni, Netra" uniqKey="Unni N" first="Netra" last="Unni">Netra Unni</name><affiliation wicri:level="4"><nlm:aff id="A2">Faculty of Applied Science and Engineering, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Applied Science and Engineering, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27354847</idno><idno type="pmc">4918865</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918865</idno><idno type="RBID">PMC:4918865</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000180</idno><idno type="wicri:Area/Pmc/Curation">000180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000180</idno><idno type="wicri:Area/Pmc/Checkpoint">000045</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000045</idno><idno type="wicri:Area/Ncbi/Merge">002014</idno><idno type="wicri:Area/Ncbi/Curation">002014</idno><idno type="wicri:Area/Ncbi/Checkpoint">002014</idno><idno type="wicri:doubleKey">0044-0086:2016:Qudrat A:theoretical:approaches:to</idno><idno type="wicri:Area/Main/Merge">000160</idno><idno type="wicri:Area/Main/Curation">000160</idno><idno type="wicri:Area/Main/Exploration">000160</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson’s Disease</title><author><name sortKey="Qudrat, Anam" sort="Qudrat, Anam" uniqKey="Qudrat A" first="Anam" last="Qudrat">Anam Qudrat</name><affiliation wicri:level="4"><nlm:aff id="A1">Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Unni, Netra" sort="Unni, Netra" uniqKey="Unni N" first="Netra" last="Unni">Netra Unni</name><affiliation wicri:level="4"><nlm:aff id="A2">Faculty of Applied Science and Engineering, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Applied Science and Engineering, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">The Yale Journal of Biology and Medicine</title><idno type="ISSN">0044-0086</idno><idno type="eISSN">1551-4056</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease is a late-onset neurodegenerative disease, characterized by both motor and non-motor symptoms. Motor symptoms include postural instability, rigidity, and tremor, while non-motor symptoms include anxiety, dementia, and depression. 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uniqKey="Cartwright M">M Cartwright</name></author><author><name sortKey="Martin, S" uniqKey="Martin S">S Martin</name></author><author><name sortKey="D Ello, S" uniqKey="D Ello S">S D’Mello</name></author><author><name sortKey="Heinrich, G" uniqKey="Heinrich G">G Heinrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaplitt, Mg" uniqKey="Kaplitt M">MG Kaplitt</name></author><author><name sortKey="Leone, P" uniqKey="Leone P">P Leone</name></author><author><name sortKey="Samulski, Rj" uniqKey="Samulski R">RJ Samulski</name></author><author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name></author><author><name sortKey="Pfaff, Dw" uniqKey="Pfaff D">DW Pfaff</name></author><author><name sortKey="O Alley, Kl" uniqKey="O Alley K">KL O’Malley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longo, Fm" uniqKey="Longo F">FM Longo</name></author><author><name sortKey="Massa, Sm" uniqKey="Massa S">SM 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